Effect and Association of circ_0084927 and microRNA-634 on Lung Cancer Cell Sensitivity to Cisplatin

To investigate the role of circ_0084927 in lung cancer cell sensitivity to cisplatin. Half-maximal inhibitory concentration value cisplatin was detected by counting kit-8. and microRNA-634 expression were determined reverse transcription quantitative polymerase chain reaction. Cell kit-8, scratch healing, colony formation as well Transwell experiments used for analyzing viability, healing rate, clone number invasive ability, respectively. Dualluciferase reporter method utilized validate targeting relationship. The half-maximal increased A549/DDP cells, whereas displayed an opposite result comparison with A549 cells (p<0.05). Relative DDP+si-NC group, optical density value, numbers invasion significantly reduced DDP+si-circ_0084927 group Optical DDP+microRNA-634 relative DDP+microRNA-NC Circ_0084927 directly bound microRNA-634. DDP+si-circ_0084927+anti-microRNA-NC DDP+si-circ_0084927+antimicroRNA- 634 Interference resistance promoting